The result showed that CCR7, CXCR3, CXCR4, CXCR5, CXCR6, CXCL13, CCL5, CCL19, CCL21, SAA1, S1PR4, PONC were significantly elevated in pancreatic tumor tissue from TCGA datasets compared with normal tissues from GTEx datasets. This evidence concerns the gene S1PR4 and pancreatic neoplasm.