AKT1 and cancer: The VEGFA-VEGFR2 signaling pathway was highlighted in the enrichment pathways of PAF-AH 1B2 KD cancer cells, and the related signaling pathway network and significantly changed genes were visualized by exploring through the Wiki Cancer network (Fig. 6A), which contained several tyrosine kinases and downstream signalling pathways, such as MAPK and PI3K/AKT, to regulate cell proliferation and growth.