TRIM8 and focal segmental glomerulosclerosis: We performed whole-exome analysis using a previously described method [8], focusing on variants in the genes that are currently known to cause FSGS or nephronophthisis (Tables S1 and S2), and identified a de novo novel heterozygous C to A transition (c.1461C > A) in the last exon of TRIM8, resulting in a premature stop codon (p.Tyr487*).