At present, the mechanism of the protective effect of HSD17B13 rs72613567 on HCC is not clear, but Chen et al. found that HSD17B13 induced an accumulation of the Huh-7 and SK-HEP-1 hepatoma cell lines in G1 phase and reduction of cells in S and G2 phase, indicated that overexpression of HSD17B13 can delay the cell cycle G1/S progression [24]. This evidence concerns the gene HSD17B13 and hepatocellular carcinoma.