Interestingly, a significant increase in AGR2 secretion was observed in response to all ER stress inducers, but the most when exposed to TUN, indicating that blocking of N-linked glycosylation associated with unfolded protein response may activate secretory pathway(s) leading to secretion of AGR2 from tumor cells (Fig. 6B and supplemental Fig. 6B). This evidence concerns the gene AGR2 and neoplasm.