The Val position in the [W/F]-[V/I]-X2-V GIM motif corresponds to the mutated AIM position in the ALS-associated L341V variant of p62 and implies that the decrease in binding affinity we previously observed for LC3B may impart broader changes in hATG8 selectivity, as the variant now presents a more GIM-like sequence. This evidence concerns the gene SQSTM1 and amyotrophic lateral sclerosis.