Our work suggests that, in the context of L. monocytogenes infection, TDP-43 recruits SIRT2 to chromatin, as it can for other DDR factors [44,45] and suggests a broader role of SIRT2 in other pathological contexts, perhaps in regulating DNA repair in ALS or other neurodegenerative illnesses. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.