However, the risk of infection with Klebsiella pneumonie despite antimicrobial prophylaxis during C5-blocking therapy [31] should be taken into consideration because this gram-negative encapsulated bacterium often produces large spectrum beta-lactamases that can inactivate antibiotics commonly recommended to prevent meningococcal infection upon exposure to eculizumab [32]. The gene discussed is LACTB; the disease is meningococcal infection.