Interestingly, one of the CNNM Mg2+binding site mutants, CNNM4-S196P, which is reportedly associated with Jalili syndrome [57], completely disrupted CNNM4’s capacity to lower intracellular Mg2+ without interfering with CNNMs ability to stimulate TRPM7-dependent divalent cation influx, as monitored by our Zn2+ influx assay (S11 Fig). The gene discussed is TRPM7; the disease is Jalili syndrome.