Low protein expressions of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH1L1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH4A1, ALDH5A1, ALDH6A1, ALDH7A1, ALDH8A1, ALDH9A1, and ALDH16A1 were found in HCC tissues, while their medium and high protein expressions were observed in normal liver tissues. The gene discussed is ALDH3B1; the disease is hepatocellular carcinoma.