The result shows that mRNA expressions of ALDH1B1, ALDH1L1, ALDH2, ALDH4A1, ALDH5A1, ALDH6A1, ALDH7A1, ALDH8A1, and ALDH9A1 were significantly lower in HCC tissues (Fig. 3). The gene discussed is ALDH8A1; the disease is hepatocellular carcinoma.