Our study showed that mRNA expressions of ALDH1B1, ALDH1L1, ALDH2, ALDH4A1, ALDH6A1, ALDH7A1, ALDH8A1, and ALDH9A1 were significantly lower in HCC tissues compared to normal tissues from the Oncomine database. This evidence concerns the gene ALDH6A1 and hepatocellular carcinoma.