PSA > 20 ng/mL had a specificity of 85% (95%CI 78–91%) and a sensitivity of 36% (95% CI 25–49%); whereas ISUP grade > 3 has a sensitivity of 62% (95% CI 49–74%) and specificity of 60% (95% CI 50–68%) for detection of metastatic disease using [18F]PSMA-1007 PET/CT in our population (Table 8). The gene discussed is KLK3; the disease is metastatic neoplasm.