In clinical practice, risk stratification tools such as D'Amico Risk Classification for Prostate Cancer and Memorial Sloan Kettering Cancer Center (MSKCC) Pre-Radical Prostatectomy nomogram use Prostate-specific antigen (PSA) level, Gleason score and clinical stage to stratify patients as low, intermediate or high-risk for prognostication and management [15]. This evidence concerns the gene KLK3 and Familial prostate cancer.