Likewise, patients with various different NF1 missense pathogenic variants at amino acid residue Arg1809 have multiple CALM with or without freckling and rarely Lisch nodules, but do not exhibit neurofibromas (Pinna et al. 2015; Rojnueangnit et al. 2015; Santoro et al. 2015). This evidence concerns the gene NF1 and plexiform neurofibroma.