MAPT and Cognitive impairment: Using a novel data-driven approach (EBM), we identified target ROIs that were broadly consistent with widely used Braak-like stages.15,26,27 Overall, these results support earlier work using [18F]flortaucipir14,22,58,59,60—and, more recently, [18F]MK624025—showing that the accumulation of pathological tau was seen mainly in the medial temporal lobe early in the disease process (ie, Aβ-positive CU individuals) and primarily in neocortical areas in Aβ-positive individuals with cognitive impairment.