Intriguingly, the FAM189A2 expression level at the metastatic sites of prostatic cancer was lower than that at the primary sites (Grasso et al, 2012; Data ref: Tomlins & Chinnaiyan, 2012); this pattern was also observed in breast cancer (National Cancer Genome Atlas Network, 2012b; Data ref: National Cancer Genome Atlas Network, 2012c), although the number of metastatic breast cancers was limited (Fig 1C). This evidence concerns the gene ENTREP1 and breast cancer.