Analysis of the Oncomine database showed that the expression of FAM189A2, but neither of its paralogs (FAM189A1 and FAM189B), was downregulated, compared with that in corresponding normal tissues, in various cancers: bladder (Data ref: Leem et al, 2008; Lee et al, 2010), breast (Curtis et al, 2012; Data ref: METABRIC, 2012), lung (Data ref: Kohno, 2011; Okayama et al, 2012), colorectal (National Cancer Genome Atlas Network, 2012a, 2012b), gastric (Data ref: Cho et al, 2008; Cho et al, 2011), and head and neck cancer (Data ref: Singh & Socci, 2008; Estilo et al, 2009) (Figs 1B and EV1). The gene discussed is ENTREP3; the disease is head and neck cancer.