Experimental evidence suggests that the “turning off” of the WNK4‐SPAK/OSR1 kinase cascade due to increased [Cl−]i contributes to the dephosphorylation of NCC in response to high K+ intake and hyperkalemia (Chen et al, 2019; Mukherjee et al, 2021). The gene discussed is SLC12A3; the disease is Hyperkalemia.