Analysis of the age at which hypertension develops, the percentage of family members with the mutation that also present hypertension, and the levels of serum K+, HCO3−, and pH (see Table 1), showed that the severity of the phenotype is related to the mutated gene with the following profile (from more to less severe): CUL3 > KLHL3 dominant > KLHL3 recessive > WNK4 > WNK1. Here, CUL3 is linked to hypertensive disorder.