also proposed that the cathepsin/pH hierarchical‐responsive en‐srNP improved caner accumulation and synergistic immunotherapy, which thoroughly ablated cancers and inhibited cancer recurrence simultaneously.[11b] Many pieces of research also demonstrated that sensitive polymers containing tertiary amine exhibited super pH‐responsive structural transformations under the stimulation of cancer acidity, which reached completion within seconds.[90] This super‐pH‐sensitive en‐srNP further impaired TME and promoted tumor synergistic immunotherapy by improving the accuracy of drug release.[91]. This evidence concerns the gene CTSS and cancer.