The response mechanism of en‐srNPs was considered as the imbalance of hydrophilic and hydrophobic materials comprised of enzyme‐responsive moieties.[116] The quinone oxidoreductase 1 (NQO1) enzyme‐mediated en‐srNP was designed by self‐assembling amphiphilic BCPs, coumarin photosensitizer, and quinone trimethyl enzyme‐sensitive block linkages.[117] Upon the NQO1 micelle endocytosis, the cancer NQO1 enzyme triggered the breakage of quinone and controlled delivery of linked photosensitizer and then generated PDT activity and fluorescent emission. The gene discussed is NQO1; the disease is cancer.