As shown in Figure 4e, the normal, SBT, and malignant tumor tissues exhibit statistically significant differences in protein and lipid fractions (normal: 0.83 ± 0.07; SBT: 0.94 ± 0.06; EC: 0.53 ± 0.05; HGSC: 0.58 ± 0.03; MC: 0.56 ± 0.05, mean ± SD), which can be attributed to the dysregulation of lipolysis and ECM reorganization (involving serum albumin) during cancer invasion.[11, 43] These lipid/protein metabolism changes indicate the pathological transformation of early tumors to highly life‐threatening malignancies. Here, ALB is linked to cancer.