PTPRC and cancer: Because pancreatic tumors contain significant percentage of inflammatory hematopoietic cells (nearly 1⁄2 of all cellular population isolated using the enzymatic digestion procedures described above (Dominguez et al., 2020)), and because of the limited cell number allotted for creating single-cell RNA expression libraries, removal of CD45-expressing cells may be necessary for the applications when the investigators are interested in capturing the minority cellular populations such as specific subsets of epithelial cancer cells or cancer-associated fibroblasts (Peng et al., 2019).