Studies combining MRI and PET imaging as a proxy for pathology showed that the load and neuroanatomical distribution of tau tracers correlate with cortical atrophic patterns on MRI,9–13 while widespread cortical Aβ deposition9 does not correlate with cortical atrophy nor clinical presentation in clinically defined Alzheimer’s disease cases.14 The gene discussed is MAPT; the disease is Alzheimer disease.