MAPT and early-onset autosomal dominant Alzheimer disease: Taken together, our findings show that, in Alzheimer’s disease, Aβ load correlates with a slightly increased cortical thickness relatively to the atrophic Alzheimer’s disease cortex, while p-tau load is the strongest contributor to regional cortical atrophy in frontal and temporal regions, and reactive microglia load is the strongest correlate of cortical atrophy in the parietal region.