MAPT and Alzheimer disease: By subgroup, both typical and atypical Alzheimer’s disease had higher Aβ (P = 0.012 and P = 0.001, respectively; Fig. 3A–C) and p-tau load (P = 0.002 and P < 0.001, respectively; Fig. 3D–F) compared to controls, whereas typical and atypical Alzheimer’s disease did not differ in load or regional distribution of Aβ (P = 1.000) or p-tau (P = 1.000).