CCND1 and neoplasm: The ultimate expression of the downstream targets cyclin D1, cyclin D2 and COX-2 were also significantly downregulated in the Anthos group for both adjacent normal (P = 0.0009, P = 0.001, and P = 0.0009, respectively) and tumor tissue samples (P = 0.0004, P = 0.03, and P = 0.03, respectively) (Figure 5).