The phosphorylation status of transphosphorylation site Y845 of the receptor tyrosine kinase (RTK), EGFR, a site noted for its activation by Src was also significantly decreased in adjacent normal (P = 0.003) and colon tumor (P = 0.01) samples taken from Anthos–treated animals over control animals. Here, NTRK1 is linked to colonic neoplasm.