Alterations in the phosphorylation status of EGFR and Src as well as downstream STAT3 in colon tumor tissues taken from the Anthos–treated, ETBF-inoculated ApcMin/+ mice support this decrease in PD-L1 expression, while the simultaneous increase in PD-L1 expression in adjacent normal tissue is supported by the IFN-γ modulation noted in this same tissue. The gene discussed is STAT3; the disease is colonic neoplasm.