Clinical trials conducted with chemopreventive agents for CRC include non-steroidal anti-inflammatory drugs such as aspirin [7] and the cyclo-oxygenase-2 (COX-2) inhibitors, calcium [8], vitamin D [9], folic acid [10], and dietary phenolics such as resveratrol [11], curcumin [12], green tea extract [13], soy isoflavones [14], black raspberry powder [15], pomegranate extract [16] and bilberry extract [17]. Here, PTGS2 is linked to colorectal carcinoma.