Furthermore, in vivo anti-polyp and anti-tumor efficacy along with corresponding mechanistic insight suggest that Anthos lead to a potent decrease in the phosphorylation status of Src, EGFR, STAT5, STAT3 and expression of key markers for proliferation and inflammation including cyclin D1, cyclin D2, COX-2, PD-L1 as well as positive chemopreventive modulation of the inflammatory environment. This evidence concerns the gene CCND2 and neoplasm.