Results also show that one week of AVP deficiency in the PCA+NIL animals caused the following effects: (i) reversion of some of the altered metabolic parameters to normal (total proteins and serum albumin and liver glycogen content), (ii) increase in the anti-inflammatory IL-10 gene expression level, (iii) decrease of both COLL-I gene expression level and deposition of type I collagen, and (iv) increase in MMP-13 gene expression level and depressed liver fibrosis (assessed by histopathology). The gene discussed is MMP13; the disease is neurohypophyseal diabetes insipidus.