TNFRSF25, a T cell costimulatory molecule, which we found to be significantly associated with BACE1-AS expression among 23 types of tumors, is correlated with the pathogenesis of liver cancer, pancreatic cancer, breast cancer, colon cancer, and leukemia and activates the NF-κB and MARK signaling pathways [35–39]. Here, TNFRSF25 is linked to familial pancreatic carcinoma.