Huangqi-Danshen decoction which mainly includes Astragali Radix (Huang-qi) and Salviae Miltiorrhizae Radix et Rhizoma (Dan-shen) significantly alleviated DN, which might be associated with the reversion of the enhanced mitochondrial fission and the inhibition of PINK1/Parkin-mediated mitophagy [22]. Here, PRKN is linked to liver dysplastic nodule.