Th cell differentiation has been reported by nearly reports in melanoma which had a strong correlation with ETV7, and this is constant with our current study [15].The immune score of BLCA patients with high expression of ETV7 was significantly higher than that of BLCA patients with low expression of ETV7, suggesting a higher degree of immune cell infiltration in the tumor microenvironment. The gene discussed is ETV7; the disease is melanoma.