For example, PAD4 levels are very high in carotid plaques (52), and citrullinated histone H3 (CitH3), double-stranded DNA (dsDNA), neutrophil elastase (NE) levels, the myocardial infarction area, and left ventricular dysfunction are related to the poor prognosis of patients with coronary atherosclerosis and myocardial infarction (19, 21, 41). The gene discussed is ELANE; the disease is myocardial infarction.