POMC and Cowden syndrome 1: The median ACTH was 109.0 (91.78–170.30) pg/ml in the CS complicated with cardiomyopathies group (n = 7), which was significantly higher than that in CS patients without cardiomyopathies, which was 68.60 (47.85–110.00) pg/ml (p = 0.0199; Table 4).