SMAD3 and Myocardial fibrosis: Based on a variety of studies on Qi-Li-Qiang-Xin, we can find that it can exert the effect of anti-myocardial apoptosis and myocardial fibrosis by inhibiting the production of inflammatory factors, reducing the production of ROS, up-regulating PGC-1α and PPARγ, inhibiting the TGF-β1/Smad3 pathway, and activating the TGF-β3/Smad7 signal pathway.