By contrast, one somatic mutation in the PTEN gene (p.Thr319Ter) was detected specifically in the adenocarcinoma components of both primary and metastatic sites (S2 and mL2), whereas the carcinoid component of both sites shared one somatic mutation in the NF1 gene (p.Arg1325Thr). The gene discussed is PTEN; the disease is adenocarcinoma.