TP53 and adenocarcinoma: In addition, the I3 adenocarcinoma showed a specific, somatic mutations in ATM (p.Gln1117Ter), TP53 (p.Gly245Asp), and CDK12 (p.Arg44Trp) genes, whereas the S1 adenocarcinoma showed a specific, somatic, missense mutations in IDH2 gene (p.Arg172Ser).