Ex vivo DHA treatment of peritoneal macrophages from mice with streptozotocin (STZ)-induced T1DM resulted in reversing the diabetes-induced changes, as increased pro-inflammatory cytokine/chemokine levels, nitric oxide (NO) secretion, NLRP3 and inducible NO synthase (iNOS) protein levels (Davanso et al., 2020). This evidence concerns the gene NOS2 and type 1 diabetes mellitus.