HSP90AA1 and glioblastoma: Here, we describe a novel treatment opportunity for GBM using the synthesized cationic supramolecular inhibitor of Hsp90 (termed “SCI-101”), which is developed for optimal crossing of the BBB in organoid models, monotherapy anticancer efficacy in 2D and 3D GBM models, and sustained expression of NK cell–activating target antigens on tumor cells for more than 72 h following treatment cessation.