Our results showed that compared with osteoblasts, CPEB3, EIF4E3, RBM34, RPS27L, RPS29 and TDRD6 were down-regulated in U2OS and 143B, while NXT2, TERT, TLR8 and ZC3HAV1 were up-regulated in osteosarcoma cells (Figure 7A). The gene discussed is TDRD6; the disease is osteosarcoma.