CDH1 and androgen insensitivity syndrome: CDH1 is important in blood-brain barrier (BBB) function (Pal et al., 1997); ischemic stress may impact endothelial cell calcium flux, thereby altering the structure and function of the BBB (Abbruscato and Davis, 1999); CDH1 was noted to be downregulated in AIS but was not found to have any predictive value (Qin et al., 2019).