Recent studies have indicated that the NF-κB pathway can be used as a target for castration-resistant PCa(McCall et al., 2012) and that the Wnt/β-catenin pathway is involved in the proliferation, invasion and metastasis of PCa (Clevers and Nusse, 2012; Zhang and Li, 2020). The gene discussed is NFKB1; the disease is posterior cortical atrophy.