Previous studies have revealed the functions of several SOCS family genes and JAK/STAT pathway in kidney cancer (Horiguchi et al., 2002c; Stofas et al., 2014; Wake and Watson, 2015; Yabe et al., 2018; Liang et al., 2020b); however, whether the expression levels of SOCS can affect the prognosis of patients with KIRC is not fully understood. Here, CISH is linked to kidney cancer.