CISH and type 2 diabetes mellitus: As shown in Figure 5B, in the KEGG pathway enrichment analysis, SOCS genes and related genes were highly enriched in the prolactin signaling pathway, JAK/STAT signaling pathway, type II diabetes mellitus, insulin signaling pathway, growth hormone synthesis, secretion and action, osteoclast differentiation, natural killer cell-mediated cytotoxicity, and vascular endothelial growth factor signaling pathway.