Another biomarker, the soluble urokinase plasminogen activator receptor (suPAR), has been shown to be significantly elevated in patients with COVID-19 (9), and stands out as a predictor of overall disease severity and outcome (10–15) and in particular of severe respiratory failure (16), and acute kidney injury (17) due to SARS-CoV-2 infection. The gene discussed is PLAUR; the disease is respiratory failure.