To definitely conclude MCC downregulation in podocytes of DKD and FSGS, we used Nephroseq data to compare the fold changes of MCC with that of podocyte marker genes, MAGI2, LMX1B, WT1, FOXC1, FOXC2, VEGFA, SYNPO, NPHS1, NPHS2, YAP1 and CD2AP, which are well known to be downregulated in the same diseases. The gene discussed is SYNPO; the disease is diabetic kidney disease.