A patient with high malnutrition (ALB <30 g/L) and anemia (Hb = 86 g/L) died of severe heart failure after refusing treatment, and another with high malnutrition (ALB <30 g/L) and diabetes (more than 10 years) died from gastrointestinal bleeding after FP remission. The gene discussed is GSTM1; the disease is nutritional deficiency disease.