Diagnoses were papilledema (19 total; 15, idiopathic intracranial hypertension 4 other high intracranial pressure), compressive (17 total; 12 chiasm, 3 intracranial, 2 orbit), non arteritic anterior ischemic optic neuropathy (16), atrophy (15), optic neuritis (14), glaucoma (4), optic nerve head edema (4), toxic (4), tract (4), inflammatory (3), Leber hereditary ON (2), dominant optic atrophy with OPA1 mutation (2), optic disk drusen (2), and one each infection, orbit inflammation and trauma. The gene discussed is OPA1; the disease is anterior ischemic optic neuropathy.