HLA-A*33:03 (71 patients, 159 controls; OR = 2.6, p = 0.0028), HLA-B*44:03 (71 patients, 159 controls; OR = 6.0, p < 0.0001), and HLA-C*07:01 (71 patients, 159 controls; OR = 4.9, p < 0.0001) exhibited a significant associations with SJS/TEN with SOC (25). This evidence concerns the gene HLA-A and toxic epidermal necrolysis.