There was a statistically significant and novel negative allele association with HLA-B*07:02 (25 patients, 15 controls; OR = 0.16, p = 0.012) and with HLA-C*07:02 (25 patients, 15 controls; OR = 0.09, p = 0.030) in a sub-group of European ancestry SJS/TEN patients (both with and without SOC) but not in their controls. The gene discussed is HLA-B; the disease is toxic epidermal necrolysis.