A focus on CM-SJS/TEN with SOC revealed that HLA-B*44:03 (49 patients, 159 controls; OR = 7.2, p < 0.0001) and HLA-C*07:01 (49 patients, 159 controls; OR = 6.1, p < 0.0001) were significantly associated with Thai CM-SJS/TEN with SOC. Here, HLA-C is linked to toxic epidermal necrolysis.