CDKN1A and open-angle glaucoma: Besides, we found that CDKN1A has the highest correlation with RELB at the transcript level (Figure 3F), and CDKN1A encodes cyclin which is regulated by kinase inhibitors (El-Deiry, 2016), indicating that RELB may control the proliferation of T cells by regulating the expression of CDKN1A. All these indicate that there are several driving factors that play an important role in the changes in the physiological mechanism of POAG.