Decreased MERCS were observed in cardiomyopathy caused by phopsholamban p. Arg14del mutation (Cuello et al., 2021), in Charcot-Marie-Tooth type 2A (CMT2A, a dominant axonal form of peripheral neuropathy due to mutation in MFN2 (Bernard-Marissal et al., 2019)) and also in conditions such as amyotrophic lateral sclerosis and frontal dementia (ALS/FTD) due to defects in fused in sarcoma (FUS) (Stoica et al., 2016). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.