LSS and cataract: Although LSS mutations with an additional mutation in Fdft1 caused cholesterol deficiency-associated cataracts in the Shumiya cataract rat (SCR) and lens-specific Lss knockout mice had cataracts, SCRs developed mature cataracts at around 11 weeks of age and cataracts were shown in lens-specific Lss knockout mice at 14 weeks of age (Mori et al., 2006; Wada et al., 2020).