MSLN and cancer: However, compared with a low level of expression in normal tissues, mesothelin is overexpressed in about 30% of all cancers, including most epithelioid mesotheliomas; adenocarcinomas of the lungs, stomach, bile ducts, endometrium and pancreas; serous ovarian cancer; squamous cell carcinomas of the head and neck, esophagus, lungs, cervix, and vulva; triple negative breast cancer, desmoplastic small cell tumors and epithelial biphasic synovial sarcomas (Chang et al., 1992; Chang and Pastan, 1996; Yang et al., 2017; Hu et al., 2019; Walcher et al., 2020).