Since mesothelin is overexpressed in several cancers and is immunogenic, the protein could be exploited as a tumor marker, unfortunately, it is not a specific antigen for cancer (Colnot et al., 2002; Ginestier et al., 2007; Feng et al., 2017; Klapdor et al., 2017; Hu et al., 2019). This evidence concerns the gene MSLN and neoplasm.