High GPx3 expression is a potential marker for the diagnosis and prognosis and can inhibit the progression in breast cancer, clear cell ovarian cancer hepatocellular carcinoma, cervical cancer and melanoma patients (Itamochi et al., 2002; Saga et al., 2008; Qi et al., 2014; Zhang et al., 2014; Chen et al., 2016; Lou et al., 2020). This evidence concerns the gene GPX3 and hepatocellular carcinoma.