GPC3 and Simpson-Golabi-Behmel syndrome: GPC3 can regulate cell proliferation in embryonic mesoderm tissue, as GPC3 gene deletion leads to giant/over growth syndrome, simpson-Golabi-Behmel syndrome (SGBS) (Simpson et al., 1975; Behmel et al., 1984; Ferlini et al., 1984; Pilia et al., 1996; Vuillaume et al., 2019).