BMP4 and myopia: In the current study, interestingly, all the four probands with these BMP4 truncations had early onset pathologic myopia, accounting for 4 of 928 probands with early onset high myopia, but in none of the 6,386 probands with other eye conditions (P = 2.58 × 10–4, Fisher’s exact test) (Figures 2A,C).