In previous studies, variants in BMP4 have been mainly reported to be associated with microphthalmia, anophthalmia, coloboma (MAC) (Bakrania et al., 2008; Reis et al., 2011) and anterior segment dysgenesis (ASGD) (Takenouchi et al., 2013) in human. This evidence concerns the gene BMP4 and microphthalmia.