Compared to cells transmigrating through meso-mimetic cultures of control MCs, significantly more tumor cells migrate through MCs cultured with ET-1 but not with BQ123 and BQ788 (Figure 8D), supporting the role of ET-1-dependent signaling in MCs to facilitate the communication between SOC and mesothelial cells, and cell invasion. This evidence concerns the gene UBXN11 and neoplasm.