Although further analyses are required to dissect the crosstalk between cancer and mesothelial cells driven by ET-1/β-arr1 in new multicellular models, which replicate more closely the disease tissues and identify new proteins involved in the activation of cancer-associated MCs, we speculate that targeting the ET-1 signaling could also interfere with the accumulation of cancer-associated MCs and with tumor colonization through the peritoneum. The gene discussed is EDN1; the disease is neoplasm.