NF−κB is widely activated in the tumor microenvironment, immune responses, inflammatory responses, and cellular differentiation, and plays essential roles in inflammation, oxidative stress, senescence, and apoptosis in IDD (Choi M. C. et al., 2019; Dong et al., 2019; Yi et al., 2019; Shao et al., 2020, 2021; Zhang et al., 2021). This evidence concerns the gene NFKB1 and intervertebral disk degenerative disorder.