To better reveal the role of the risk score in the regulation of the tumor microenvironment, the cytokines and chemokines characterizing different risk groups were extracted from the published literature (Barbie et al., 2009; Zeng et al., 2019), for example, PDGFRA, TGFB2, SMAD9, TWIST1, CLDN3, TGFBR2, ACTA2, COL4A1, ZEB1, and VIM are correlated with the transcripts of TGF-beta or EMT pathway, and TNF, IFNG, TBX2, GZMB, CD8A, PRF1, GZMA, CXCL9, and CXCL10 are thought to be related to the transcripts of immune activation. This evidence concerns the gene SMAD9 and neoplasm.