SPRY2 and congenital diaphragmatic hernia: Rodent models of CDH present with a reduction in the number of branches (Baird et al., 2008; Fox et al., 2018; Nguyen et al., 2019) and reduced expression of both Spry2 (Friedmacher et al., 2013) and Fgf10 (Teramoto et al., 2003), although it remains unclear whether these effects are due to changes in the mechanical environment surrounding the lungs, biochemical signaling from nitrofen induction of CDH, or both (Keijzer et al., 2000).