Zhong et al. report that knockdown of METTL3 or YTHDF2 in vitro enhanced the stability and expression of peroxisome proliferator-activator receptor alpha (PPARα) mRNA, leading to decreased lipid accumulation in a hepatocellular carcinoma cell line (HepG2) (Zhong et al., 2018). Here, PPARA is linked to hepatocellular carcinoma.